Four-stage atherosclerotic vascular occlusion model

The four-stage atherosclerotic vascular occlusion model demonstrates four stages of atherosclerosis:

1. Asymptomatic stage or subclinical stage: the process varies in length, including from earlier pathological changes until atherosclerosis has formed, but there are no clinical manifestations of organ or tissue involvement.

2. Ischemia period: Symptoms of organ ischemia due to vascular stenosis.

3. Necrosis stage: the performance of organ tissue necrosis due to the occlusion of the lumen due to acute thrombosis in the blood vessel.

4. Fibrosis stage: long-term ischemia, fibrosis and atrophy of organs and tissues cause symptoms.